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Single or dual microfocus X-ray diffractometer for all your crystallography needs

A fast and agile single crystal X-ray diffractometer for small molecule 3D structure analysis

  • Extremely high performance due to bright source, noise-free X-ray detector and fast goniometer speeds
  • Continuously variable divergence slit option lets you resolve reflections from long unit cells.
  • Minimal downtime with longer X-ray tube lifetime - supported by online diagnostics and troubleshooting
  • Compact design to fit in your laboratory
XtaLAB Synergy-S
Small Molecule, Protein
Academic research, Chemistry, Materials science, Geology & minerals, Pharmaceuticals
Chemical crystallography, Protein crystallography, Single crystal X-ray diffraction

With your success utmost in our minds, we have developed the XtaLAB Synergy-S X-ray diffractometer for single crystal X-ray diffraction. Using a combination of leading edge components and user-inspired software tied together through a highly parallelized architecture, the XtaLAB Synergy-S produces fast, precise data in an intelligent fashion. The system is based around the PhotonJet-S series of microfocus X-ray sources that incorporate continuously variable divergence slits. These third generation sources have been designed to maximize X-ray photons at the sample by using a combination of new optics, new, longer life, tubes and an improved alignment system. PhotonJets are available in Cu, Mo or Ag wavelengths in either a single or dual source configuration. The XtaLAB Synergy-S single crystal X-ray diffractometer comes with kappa goniometer that incorporates fast motor speeds and a unique telescopic two-theta arm to provide total flexibility for your diffraction experiment. The system is also equipped with your choice of HPC X-ray detector, including the HyPix-6000HE, PILATUS3 R 200K, PILATUS3 R 300K or EIGER 1M.


Product name XtaLAB Synergy-S
Technique Single crystal X-ray diffraction
Benefit 3D structural analysis of molecules 
Technology Single crystal X-ray diffractometer
Core attributes Single or dual X-ray source diffractometer with hybrid pixel array detector and kappa goniometer
Core options Oxford Cryostream Cooler and XtalCheck-S
Computer External PC, MS Windows® OS
Core dimensions 1300 (W) x 1875 (H) x 850 (D) mm
Mass  550 kg (core unit)
Power requirements 1Ø, 90-130V 15A or 180-260V 4A


The following accessories are available for this product
ELement ANalyzer

The ELement ANalyzer is a state-of-the-art attachment that allows us to obtain qualitative information on elements in a single crystal at the same time as X-ray diffraction data collection for a single crystal structural analysis. By measuring the X-ray fluorescence spectrum emitted during X-ray diffraction experiments with the ELement ANalyzer, it becomes possible to perform elemental analysis on a single grain of crystal. The ELement ANalyzer can be used for confirmation the presence of central metal(s) in a mononuclear or polynuclear complex or solvent in a crystal for small molecule X-ray crystallography. There is a broad range of possible applications of the ELement ANalyzer in scientific fields.

ELement ANalyzer

ELement ANalyzerは単結晶試料の回折測定と元素分析(定性分析)を並行して行える画期的なアタッチメントです。回折測定中に試料から放出される蛍光X線をELement ANalyzerで計測することにより、結晶に含まれている元素を同定します。Mo線源の装置に組み合わせた場合、P(リン)より重い元素であれば、同定することができます*。RAPIDシリーズやSaturnシリーズなどの単結晶X線回折装置に組み合わせることができ、既存の装置を改造することなく取り付けが可能です。錯体の中心金属の有無や種類、結晶溶媒の有無を数分で確認できるため、無駄となる測定を減らし、研究を効率的に進めることができます。また、多核錯体の確認にも威力を発揮します。

Oxford Cobra

The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.

Oxford Cryostream 800

The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.


The XtalCheck system includes software that facilitates both visual and diffraction imaging of crystallization experiments. With the XtalCheck system, one can easily survey many crystallization experiments by eliminating the need to harvest and cryo-cool samples. Moreover, one can perform serial crystallography experiments, by collecting data from multiple crystals, to achieve complete data sets that can be used for structure solution.


手動タイプ PlateMate

  • シンプルかつ軽量で扱いやすいデザイン
    ゴニオメーターヘッドと同じマウント機構を採用。既存のX線回折装置に簡単に取り付けることができます。SBS規格に準拠した結晶化プレートに対応可能で、MiTeGen社製 In Situ–1 Crystallization Plateでの測定に適したデザインです。
  • 簡単かつ正確なセンタリング機構
  • 結晶化プレート中の結晶を測定
  • 構造解析用のデータ収集も可能

電動タイプ XtalCheck

  • GUIからコントロール

Papers published using the XtaLAB Synergy-S

  1. Lin Lim F P, Tan K C, Luna G, Tiekink E R T, Dolzhenko A V. “ A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism.” Tetrahedron (2019), 75(15): 2314-2321.
  2. Wiscons R A, Coropceanu V, Matzger A J. “Quaternary Charge-Transfer Solid Solutions: Electronic Tunability through Stoichiometry.” Chem. Mater. (2019), available online 13 March
  3. Takahashi Y, Uehara T, Matsuhashi C, Yamaji M, Mutai T, Yoshikawa I, Houjou H, Kitagawa K, Suenobu T, Maki S, Hirano T. “Spectroscopic properties of push-pull 2-(4-carboxyphenyl)-6-dimethylaminobenzothiazole derivatives in solution and the solid state.” J. Photochem. Photobio. A:Chem. (2019), 376: 324-332.
  4. Konkankit C C, Vaughn B A, MacMillan S N, Boros E, Wilson J J. “Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent.” Inorg. Chem. (2019), available online 22 Feb
  5. King A P, Gellineau H A, MacMilan S N, Wilson J J. “Physical properties, ligand substitution reactions, and biological activity of Co (III)-Schiff base complexes.” Dalton Transactions (2019), just accepted 11 Jan.
  6. Grey I E, Mumme W G, Downes P J, Grguric B A, Gable R W. “Segelerite from the mount Deverell variscite deposit, Western Australia. Hydrogen bonding and relationship to jahnsite.” European Journal of Mineralogy (2019), available online 10 Jan
  7. Malmberg R, Bachmann M, Blacque O, Venkatesan K. “Thermally Robust and Tunable Phosphorescent Gold(III) Complexes Bearing (N^N)-type Bidendates as Ancillary Chelates.” Chemistry – A European Journal (2019), available online 7 Jan
  8. Tan Y J, Tan Y S Yeo C I Chew J, Tiekink E R T. “In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR’)}2.” J. Inorg. Chem. (2019) 192: 107-118
  9. Ali M O, Lasseter J C, Żurawiński R, Pietrzak A, Pecyna J, Wojciechowski J, Friedli A C, Pociecha D, Kaszyński P. “Thermal and Photophysical Properties of Highly Quadrupolar Liquid-Crystalline Derivatives of the [closo-B12H12]2- Anion.” Chemistry – A European Journal (2018) just published 17 December
  10. Zhen J, Zhou W, Chen M, Li B, Jia L, Wang M, Yang S. “Pyridine-functionalized fullerene additive enabling coordination interactions with CH3NH3PbI3 perovskite towards highly efficient bulk heterojunction solar cells.” Journal of Materials Chemistry A (2019), 7: 2754-2763
  11. Fu J, Ren Z, Bacsa J, Musaev D G, Davies H M L. “Desymmetrization of cyclohexanes by site- and stereoselective C-H functionalization.” Nature Letters (2018), 564: 395-399
  12. Akagi S, Horiguchi T, Fujii S, Kitamura N. “Terminal Ligand (L) Effects on Zero-Magnetic-Field Splitting in the Excited Triplet States of [{Mo6Br8}L6]2- (L= Aromatic carboxylates).” Inorg. Chem. (2019), 58(1): 703-714
  13. Molcanov K, Jelsch C, Landeros B, Hernández-Trujilo J, Wenger E, Stilinović V, Kojic-Prodic B, Escudero-Adán E C. “Partially covalent two-electron/multicentric bonding between semiquinone radicals.” Cryst. Growth Des. (2019) 19: 391-402
  14. Ogawa A, Oohora A, Hayashi T. “Synthesis and Characterization of meso-Substituted Cobalt Tetrahydrocorrin and Evaluation of its Electrocatalytic Behavior Toward CO2 Reduction and H2 Evolution.” Inorg. Chem. (2018) 57(23): 14644-14652
  15. Yang Y, Zhang S-S, Zhao Q-Q, Wang X-P, Tung C-H, Sun D. “Construction of Crystalline One-Dimensional Infinite Argentophilic Silver Alkynyl Assemblies and their Luminescence Properties.” Eur. J. Inorg. Chem. (2018), 47
  16. Lipowska M, Klenc J, Taylor A T, Marzilli L G. “fac-99m Tc/Re-tricarbonyl complexes with tridendate aminocarboxyphosphonate ligands: suitability of the phosphonate group in chelate ligand design of new imaging agents.” Inorg. Chim. Acta (2019) 486: 529-537
  17. Gradstein F M, Waskowska A, Kopaevich L, Watkins D K, Friis H, Pérez Panera J. “Berriasian planktonic foraminifera and calcareous nannofossils from Crimea Mountains, with reference to microfossil evolution.” Swiss Journal of Palaeontology (2018), published online 7 November
  18. Alexandropoulos D I, Alaimo A A, Sun D, Stamatatos T C. “A New {Dy5} Single-Molecule Magnetic Bearing the Schiff Base Ligand N-Naphthalidene-2-amino-5-chlorophenol.” Magnetochemistry (2018) 4(4): 48
  19. Getmanenko Y A, Mullins C S, Nesterov V N, Lake S, Risko C, Johnston-Halperin E. “Magnetic ordering in a vanadium-organic coordination polymer using a pyrrolo[2,3-d:5,4-d’]bis(thiazole)-based ligand.” RSC Adv. (2018) 8: 36223-36232
  20. Worrell A, Sun D, Mayans J, Lampropoulous C, Escuer A, Stamatatos T C. “Oximato-Based Ligands in 3d/4f-Metal Cluster Chemistry: A Family of {Cu3Ln} Complexes with a “Propeller”-like Topology and Single-Molecule Magnetic Behavior.” Inorg. Chem. (2018) 57(21): 13944-13952
  21. VanGelder L E, Petel B E, Nachtigall O, Martinez G, Brennessel W W, Matson E M. “Organic Functionalization of Polyoxovanadate-alkoxide Clusters: Improving the Solubility of Multimetallic Charge Carriers for Nonaqueous Redox Flow Batteries.” ChemSusChem (2018), first published 15 Oct
  22. Tan Y S, Chun, H Z, Jotani M M, Tiekink E R T. “Steric control of supramolecular association in structures of Zn(S2COR)2 with N,N’-bis(pyridine-4ylmethyl)oxalamide.” Z. Kristallogr. Cryst. Mater. (2018), first published 8 Oct
  23. Pejić J, Vušak D, Szalontai G, Prugovečki B, Mrvoš-Sermek D, Matković-Čalogović D, Sabolović J. “Disorder at the Chiral Cα Center and Room Temperature Solid-State cis-trans Isomerization; Synthesis and Structural Characterization of Copper(II) Complexes with D-allo, L-Isoleucine.” Crys. Growth Des. (2018) 18(9): 5138-5154
  24. Siu J C, Sauer G S, Saha A, Macey R L, Fu N, Chauviré T, Lancaster K M, Lin S. “Electrochemical Azidooxygenation of Alkenes Mediated by a TEMPO-N3 Charge-Transfer Complex.” J. Am. Chem. Soc. (2018) 140(39): 12511-12520
  25. Kadassery K J, MacMillan S N, Lacy D C. “Biphosphine phenol and phenolate complexes of Mn (I): manganese(I) catalyzed Tishchenko reaction.” Dalton Transactions (2018) 47: 12652-12655!divAb...
  26. Stone I B, Jermaks J, MacMillan S N, Lambert T H. “The Hydrazine-O2 Redox Couple as a Platform for Organocatalytic Oxidation: Benzo[c]cinnoline-Catalyzed Oxidation of Alkyl Halides to Aldehydes.” Angew. Chem. Int. Ed. (2018) 57(38)
  27. Meyer R L, Brennessel W W, Matson E M. “Synthesis of a gallium-functionalised polyoxovanadate-alkoxide cluster: Toward a general route for a heterometal installation.” Polyhedron (2018), 156: 303-311
  28. Ravat P, Šolomek T, Häussinger D, Blacque O, Juríček M. “Dimethylcethrene: A Chiroptical Diradicaloid Photswitch.” J. Am.. Chem Soc. (2018) 140: 10839 – 10847
  29. Shapiro J A, Morrison K R, Chodisetty S S, Musaev D G, Wuest W M. “Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product.” Org. Lett. (2018), 20(18): 5922-5926
  30. Zhao C, Schwartz T, Stöger B, White F J, Chen J, Ma D, Fröhlich J, Kautny P. “Controlling excimer formation in indolo[3,2,1-jk]carbazole/9H-carbazole based host materials for RGB PhOLEDs” J. Mat. Chem. C. (2018), 6: 9914-9924
  31. Movassaghi S, Leung E, Hanif M, Lee B Y T, Holtkamp H U, Tu J K Y, Söhnel T, Jamieson S M F, Hartinger C G. “A Bioactive L-Phenylalanine-Derived Arene in Miltitargeted Organoruthenium Compounds: Impact on the Antiproliferative Activity and Mode of Action” Inorg. Chem (2018) 57(14): 8521-8529
  32. Su Y, Su H-F, Wang Z, Li Y, Schein S, Zhao Q, Wang X, Tung C-H, Sun D. “Three Silver Nests Capped by Thiolate/Phenylphosphonate.” Chemistry:A European Journal (2018), 24(56): 15096-15103
  33. Wu Y, Halat D M, Wei F, Binford T, Seymour I D, Gaultois M W, Shaker S, Wang J, Grey C P, Cheetham A K. “Mixed X-site formate-hypophosphite hybrid perovskites.” Chemistry: A European Journal (2018), 24(44): 11309-11313
  34. Morgan M T, Yang B, Harankhedkar S, Nabatilan A, Bourassa D, McCallum A M, Sun F, Wu R, Forest C R, Fahrni C J. “Stabilization of aliphatic phosphines by auxillary phosphine sulfides offers zeptomolar affinity and unprecedented selectivity for probing biological Cu(II).” Angew. Chem (2018) 130(31): 9859-9863
  35. Scholl K, Dillashaw J, Timpy E, Lam Y, DeRatt L, Benton T R, Powell J P, Houk K N Morgan J M. “Quinine-Promoted, Enantioselective Boron-Tethered Diels-Alder Reaction by Anomeric Control of Transition-State Conformation.” J. Org Chem. (2018) 83: 5756-5765
  36. Akondi S M, Gangireddy P, Pickel T C, Liebeskind L S. “Aerobic, Diselenide-Catalyzed Redox Dehydration: Amides and Peptides.” Org. Lett. (2018) 20: 538-541
  37. Cundari T R, Jacobs B P, MacMillan S N, Wolczanski P T. “Dispersion forces play a role in (Me2IPr)Fe(=NAd)R2 (Ad = adamantly; R=neoPe, 1-nor) insertions and Fe-R bond dissociation enthalpies (BDEs)” Dalton Transactions (2018) 47: 6025-6030!divAbs...
  38. Vaccarello D N, O’Connor K S, Iacono P, Rose J M, Cherian A E, Coates G W. “Synthesis of Semicrystalline Plyolefin Materials: Precision Methyl Branching via Stereoretentive Chain Walking.” J. Am. Chem. Soc. (2018) 140(20): 6208-6211
  39. Molčanov K, Mou Z, Kertesz M, Kojić-Prodić B, Stalke D, Demeshko S, Šantić A, Stilinović. “Two-electron / multicenter – pancake bonding in π-stacked trimers in a salt of tetrachloroquinone anion.” Chemistry: A European Journal, (2018) 24(33): 8292-8297
  40. Milić J, Zalibera M, Talaat D, Nomrowski J, Trapp N, Ruhlmann L, Boudon C, Wenger O S, Savitsky A, Lubitz W, Diederich F. “Photoredox-Switchable Resorcin[4]arene Cavitands: Radical Control of Molecular Gripping Machinery via Hydrogen Bonding.” Chemistry: A European Journal, (2017) 24(6): 1431-1440
  41. Haberland S, Finke A D, Kerisit N, Katan C, Trolez Y, Gawel P, Leito I, Lõkov M, Järviste R, Kaupmees K, Trapp N, Ruhlmann L, Boudon C, Himmel D, Diederich F. “Enhancement of Push-Pull Properties of Pentafulvene and Pentafulvene Derivatives by Protonation at Carbon.” Eur J. Org. Chem., (2018) 6:739-749
  42. Hao W, Harenberg J H, Wu X, MacMilan S N, Lin S. “Diastereo- and Entatioselective Formal [3 + 2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed radical Redox Relay” J. Am. Chem. Soc. (2018) 140(10): 3514-3517
  43. Ye K-Y, Pombar G, Fu N, Sauer G S, Keresztes I, Lin S. “Anodically Coupled Electrolysis for the Heterodifunctionalization of Alkenes.” J. Am. Chem. Soc. (2018) 140(7): 2438-2441
  44. Junker A K, Hill L R, Thompson A L, Faulkner S, Sørensen T J. “Shining light on the antenna chromophore in lanthanide based dyes.” Dalton Trans., (2018) 47: 4794-4803
  45. Nievergelt P P, Babor M, Čejka J, Spingler B. “A high-throughput screening method for the nano-crystallization of salts of organic cations.” Chem. Sci., (2018) 9: 3716-3722 An additional news article is available at
  46. Sarkar K, Dastidar P. “Supramolecular hydrogel derived from a C3-symmetric boronic acid derivative for stimuli-responsive release of insulin and doxorubicin.” Langmuir (2018) 34(2): 685-692.
  47. Urgiles J, Nathan S R, MacMillan S N, Wilson J J. “Dinuclear nitrido-bridged ruthenium complexes bearing diimine ligands.” Dalton Trans. (2017) 46: 14256-14263.!divAbs...
  48. Hao W, Wu X, Sun J Z, Siu J C, MacMillan S, Lin S. “Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes.” J. Am. Chem. Soc. (2017) 139 (35): 12141-12144.
  49. Phukkaphan N, Cruickshank D L, Murray K S, Phonsri W, Harding P, Harding D. J. “Hysteretic spin crossover driven by anion conformational change.” Chem. Comm. (2017) 53: 9801-9804.!divAbs...
  50. Riwar L-J, Trapp N, Kuhn B, Diederich F. “Substituent Effects in Parallel-Displaced π–π Stacking Interactions: Distance Matters.” Angew. Chem. Int. Ed. (2017) 56 (37): 11252-11257.
  51. Diederich F, Trapp N, Wörle M. “Small Molecule Crystallography in the Laboratory of Organic Chemistry at ETH Zürich.” Israel Journal of Chemistry (2017) 57 (1-2): 39-54.
  52. Gropp C, Husch T, Trapp N, Reiher M, Diederich F. “Dispersion and Halogen-Bonding Interactions: Binding of the Axial Conformers of Monohalo- and (±)-trans-1,2-Dihalocyclohexanes in Enantiopure Alleno-Acetylenic Cages.” J. Am. Chem. Soc. (2017) 139 (35): 12190-12200