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Customized single crystal diffraction system with microfocus rotating anode generator

X-ray Crystal structure determination for macromolecules and chemicals

  • Customized systems for structural biology and chemical crystallography utilizing a high flux microfocus source
  • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
  • Four-circle goniometer to provide completeness and redundancy for your data sets
  • HPC detector with single pixel point spread function and true shutterless data collection
  • Dual ports allow for various combinations of crystallography and SAXS ports
  • Options for in situ crystallography and automated mounting for cryo-protected samples
XtaLAB Synergy Custom
Protein, Small Molecule, SAXS
Academic research, Chemistry, Pharmaceuticals, Materials science, Geology & minerals
Chemical crystallography, Protein crystallography, SAXS (biological), Single crystal X-ray diffraction

XtaLAB Synergy Custom

We realize that standard systems may not fit the needs for every lab, so we also offer XtaLAB Synergy Custom single crystal X-ray diffractometers for those labs who want to take advantage of dual ports or want to integrate special components, such as ACTOR sample changers. Additionally, for laboratories that want even greater flux we offer the FR-X based diffraction systems.

HPC detector

XtaLAB XtaLAB Synergy Custom systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, such as the HyPix-6000HE, PILATUS or EIGER. HPC detectors are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB Synergy Custom systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments.

Dual Port Capability

The XtaLAB Synergy Custom system includes a dual port, microfocus rotating anode X-ray generator. With XtaLAB Synergy Custom systems, you can configure to have dual single crystal ports or you can configure the second port with a small angle X-ray scattering system, such as the BioSAXS-2000. Additionally, the XtaLAB Synergy Custom comes in a custom designed enclosure with your choice of table size, to accommodate accessory equipment, such as an ACTOR system or microscope close to the goniometer. Thus, the versatility offered by the XtaLAB Synergy Custom system provides the most flexibility possible for your structural biology program.

Specifications

Product name XtaLAB Synergy Custom
Technique Single crystal X-ray diffraction
Benefit 3D structural analysis of molecules
Technology Customizable single crystal X-ray diffractometer
Core attributes X-ray diffractometer with rotating anode X-ray source and HPC detector
Core options Oxford Cryostream cooler, ACTOR, BioSAXS-2000, Dual Port
Computer External PC, MS Windows® OS
Core dimensions Varies with configuration
Mass Varies with configuration
Power requirements Varies with configuration

Accessories

The following accessories are available for this product
ACTOR

ACTOR is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection.

ELement ANalyzer

The ELement ANalyzer is a state-of-the-art attachment that allows us to obtain qualitative information on elements in a single crystal at the same time as X-ray diffraction data collection for a single crystal structural analysis. By measuring the X-ray fluorescence spectrum emitted during X-ray diffraction experiments with the ELement ANalyzer, it becomes possible to perform elemental analysis on a single grain of crystal. The ELement ANalyzer can be used for confirmation the presence of central metal(s) in a mononuclear or polynuclear complex or solvent in a crystal for small molecule X-ray crystallography. There is a broad range of possible applications of the ELement ANalyzer in scientific fields.

ELement ANalyzer

ELement ANalyzerは単結晶試料の回折測定と元素分析(定性分析)を並行して行える画期的なアタッチメントです。回折測定中に試料から放出される蛍光X線をELement ANalyzerで計測することにより、結晶に含まれている元素を同定します。Mo線源の装置に組み合わせた場合、P(リン)より重い元素であれば、同定することができます*。RAPIDシリーズやSaturnシリーズなどの単結晶X線回折装置に組み合わせることができ、既存の装置を改造することなく取り付けが可能です。錯体の中心金属の有無や種類、結晶溶媒の有無を数分で確認できるため、無駄となる測定を減らし、研究を効率的に進めることができます。また、多核錯体の確認にも威力を発揮します。

Oxford Cobra

The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.

Oxford Cryostream 800

The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.

XtalCheck

The XtalCheck system includes software that facilitates both visual and diffraction imaging of crystallization experiments. With the XtalCheck system, one can easily survey many crystallization experiments by eliminating the need to harvest and cryo-cool samples. Moreover, one can perform serial crystallography experiments, by collecting data from multiple crystals, to achieve complete data sets that can be used for structure solution.

XtalCheck

手動タイプ PlateMate

  • シンプルかつ軽量で扱いやすいデザイン
    ゴニオメーターヘッドと同じマウント機構を採用。既存のX線回折装置に簡単に取り付けることができます。SBS規格に準拠した結晶化プレートに対応可能で、MiTeGen社製 In Situ–1 Crystallization Plateでの測定に適したデザインです。
  • 簡単かつ正確なセンタリング機構
    水平および垂直方向に搭載した目盛付きのレールに沿って結晶化プレートを動かすことで、すべてのウェルに対して簡単にセンタリングすることができます。また、微調整機構により、微小な結晶であっても正確なセンタリングが可能です。
  • 結晶化プレート中の結晶を測定
    見分けのつきにくいタンパク質結晶と塩・沈殿剤などの結晶を、ドロップ内から取り出すことなく迅速に判別し、さらに分解能などの品質をチェックできます。
  • 構造解析用のデータ収集も可能
    スクリーニング目的のX線回折像取得のみならず、構造解析用の回折強度データの収集も可能です。結晶化溶媒から取り出すだけで損傷してしまうような特殊な結晶も、その環境下で測定できます。

電動タイプ XtalCheck

  • GUIからコントロール
    すべての機能はGUIから操作できます。
    モーター制御により、微小な結晶であっても正確なセンタリングが可能です。また、複数のウェルや、ドロップ内の複数の結晶を事前に指定することで、簡単な操作で複数の結晶を一度に評価できます。