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Pharmaceuticals

Elemental / phase analysis to molecular structure

In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and designed. In the recent past, most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach, using so-called "rational drug design", has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge. Given this importance, Rigaku has been at the forefront in the development of single crystal diffraction for both macromolecular and small molecule structure determination. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.

X-ray powder diffraction is extensively used in the drug discovery, design, development and formulation processes to obtain critical knowledge about pharmaceutical products. Many parameters required by the FDA, legal patent issues and drug performance are only accessible by employing XRD. With the introduction of systems specifically developed with the pharmaceutical industry in mind, XRD is now both cost-effective and easy-to-use. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. In addition, crystal structure determination, the study of non-ambient behavior, and overall morphology help to provide a complete understanding of the properties of a pharmaceutical agent.

Pharmaceuticals

Rigaku recommends the following systems:


  • Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab.

  • New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

  • Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

  • Provides the industry’s widest and most comprehensive range of raw material identification and finished product authentication in a handheld, sealed platform

  • A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.

  • An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples

  • Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

  • Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

  • High-performance, multi-purpose XRD system for applications ranging from R&D to quality control

  • User-inspired data collection and data processing software for small molecule and protein crystallography.

  • Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

  • Automated crystal transport, orientation and retrieval robot

  • High power, tube below, sequential WDXRF spectrometer with Smart Sample Loading System (SSLS)

  • High power, tube above, sequential WDXRF spectrometer with new ZSX Guidance expert system software

  • High power, tube above, sequential WDXRF spectrometer

  • Performance EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin-films

  • PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography

  • Small angle X-ray scattering (SAXS) Kratky camera system

  • New variable collimator small spot 60 kV EDXRF system featuring QuantEZ software.

  • EDXRF spectrometer with powerful Windows® software and optional FP.

  • Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components

  • High-performance, Cartesian-geometry EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin films

  • Ultra-high resolution nanotomography using parallel beam geometry

  • TG-DTA is a hyphenated technology composed of simultaneous thermal analysis (STA).

     

     

  • 2D X-ray detector with latest semiconductor technology designed for home lab diffractometers

  • Compact, highly sensitive X-ray detector for single crystal applications

  • A unique curved single crystal X-ray diffraction detector

  • High-resolution benchtop microtomography of large samples

Application notes

The following application notes are relevant to this industry