Elemental / phase analysis to molecular structure
In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and designed. In the recent past, most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach, using so-called "rational drug design", has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge. Given this importance, Rigaku has been at the forefront in the development of single crystal diffraction for both macromolecular and small molecule structure determination. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.
X-ray powder diffraction is extensively used in the drug discovery, design, development and formulation processes to obtain critical knowledge about pharmaceutical products. Many parameters required by the FDA, legal patent issues and drug performance are only accessible by employing XRD. With the introduction of systems specifically developed with the pharmaceutical industry in mind, XRD is now both cost-effective and easy-to-use. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. In addition, crystal structure determination, the study of non-ambient behavior, and overall morphology help to provide a complete understanding of the properties of a pharmaceutical agent.
Rigaku recommends the following systems:
Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab.
New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification
Provides the industry’s widest and most comprehensive range of raw material identification and finished product authentication in a handheld, sealed platform
A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.
An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples
Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator
Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments
High-performance, multi-purpose XRD system for applications ranging from R&D to quality control
User-inspired data collection and data processing software for small molecule and protein crystallography.
Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers
High power, tube below, sequential WDXRF spectrometer with Smart Sample Loading System (SSLS)
High power, tube above, sequential WDXRF spectrometer with new ZSX Guidance expert system software
Performance EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin-films
Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components
High-performance, Cartesian-geometry EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin films
2D X-ray detector with latest semiconductor technology designed for home lab diffractometers
