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Chemical / small molecule crystallography

Determine the three dimensional structure of molecules

Sometimes referred to as small molecule crystallography, this technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three dimensional structure of molecules. The technique involves the use of crystallography to study problems which are primarily of a chemical nature and provides accurate and precise measurements of molecular dimensions in a way that no other method can approach. Chemical crystallography may be applied to compounds of both chemical and biological interest, including: new synthetic chemicals, catalysts, pharmaceuticals, and natural products. A frequent use is the identification of natural products, or of the products of synthetic chemistry experiments; however, detailed molecular geometry, intermolecular interactions and absolute configuration can also be studied.

  • Crystal structure determination
  • Molecular structure and geometry
  • Absolute structure and configuration
  • Single crystal diffraction
  • Powder diffraction,
    • Ambient and non-ambient conditions
    • Displacement parameters
    • Charge density
    • Intermolecular interactions
    • Structure correlation
    Chemical / small molecule crystallography

    Rigaku recommends the following products:

    • Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab.

    • A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.

    • An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples

    • Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

    • Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

    • User-inspired data collection and data processing software for small molecule and protein crystallography.

    • Automated crystal transport, orientation and retrieval robot

    • Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality

    • Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components

    • Compact, highly sensitive X-ray detector for single crystal applications

    • A unique curved single crystal X-ray diffraction detector

    • High resolution X-ray detectors for X-ray diffractometers from DECTRIS

    • Single wavelength Confocal Max-Flux (CMF) optics for protein crystallography

    Application notes

    The following application notes are relevant to this technique