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Customized single crystal diffraction system with microfocus rotating anode generator

X-ray Crystal structure determination for macromolecules and chemicals

  • Customized systems for structural biology and chemical crystallography utilizing a high flux microfocus source
  • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
  • Four-circle goniometer to provide completeness and redundancy for your data sets
  • HPC detector with single pixel point spread function and true shutterless data collection
  • Dual ports allow for various combinations of crystallography and SAXS ports
  • Options for in situ crystallography and automated mounting for cryo-protected samples
XtaLAB Synergy Custom
Protein, Small Molecule, SAXS
Academic research, Chemistry, Pharmaceuticals, Materials science, Geology & minerals
Chemical crystallography, Protein crystallography, SAXS (biological), Single crystal X-ray diffraction

XtaLAB Synergy Custom

We realize that standard systems may not fit the needs for every lab, so we also offer XtaLAB Synergy Custom single crystal X-ray diffractometers for those labs who want to take advantage of dual ports or want to integrate special components, such as ACTOR sample changers. Additionally, for laboratories that want even greater flux we offer the FR-X based diffraction systems.

HPC detector

XtaLAB XtaLAB Synergy Custom systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, such as the HyPix-6000HE, PILATUS or EIGER. HPC detectors are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB Synergy Custom systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments.

Dual Port Capability

The XtaLAB Synergy Custom system includes a dual port, microfocus rotating anode X-ray generator. With XtaLAB Synergy Custom systems, you can configure to have dual single crystal ports or you can configure the second port with a small angle X-ray scattering system, such as the BioSAXS-2000. Additionally, the XtaLAB Synergy Custom comes in a custom designed enclosure with your choice of table size, to accommodate accessory equipment, such as an ACTOR system or microscope close to the goniometer. Thus, the versatility offered by the XtaLAB Synergy Custom system provides the most flexibility possible for your structural biology program.

Specifications

Product name XtaLAB Synergy Custom
Technique Single crystal X-ray diffraction
Benefit 3D structural analysis of molecules
Technology Customizable single crystal X-ray diffractometer
Core attributes X-ray diffractometer with rotating anode X-ray source and HPC detector
Core options Oxford Cryostream cooler, ACTOR, BioSAXS-2000, Dual Port
Computer External PC, MS Windows® OS
Core dimensions Varies with configuration
Mass Varies with configuration
Power requirements Varies with configuration

Accessories

The following accessories are available for this product
ACTOR

ACTOR is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection.

ELement ANalyzer

The ELement ANalyzer is a state-of-the-art attachment that allows us to obtain qualitative information on elements in a single crystal at the same time as X-ray diffraction data collection for a single crystal structural analysis. By measuring the X-ray fluorescence spectrum emitted during X-ray diffraction experiments with the ELement ANalyzer, it becomes possible to perform elemental analysis on a single grain of crystal. The ELement ANalyzer can be used for confirmation the presence of central metal(s) in a mononuclear or polynuclear complex or solvent in a crystal for small molecule X-ray crystallography. There is a broad range of possible applications of the ELement ANalyzer in scientific fields.

Oxford Cobra

The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.

Oxford Cryostream 800

The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.

XtalCheck

The XtalCheck system includes software that facilitates both visual and diffraction imaging of crystallization experiments. With the XtalCheck system, one can easily survey many crystallization experiments by eliminating the need to harvest and cryo-cool samples. Moreover, one can perform serial crystallography experiments, by collecting data from multiple crystals, to achieve complete data sets that can be used for structure solution.