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Drug discovery

Protein crystallization and X-ray crystallography

In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and designed. In the recent past, most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach, using so-called "rational drug design", has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge. Given this importance, Rigaku has been at the forefront in the development of single crystal diffraction for both macromolecular and small molecule structure determination. Our products range from crystallization screens to crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.

Drug discovery

Rigaku recommends the following systems:


  • Fast, flexible single crystal X-ray diffractometer with the latest generation sources and HPC X-ray detectors, perfect for any crystallography lab.

  • Single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator

  • Versatile and high-flux dual-wavelength (DW) X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments

  • Curved imaging plate (IP) XRD system features an extremely large aperture and a choice of rotating anode or sealed tube X-ray sources

  • User-inspired data collection and data processing software for small molecule and protein crystallography.

  • Automated crystal transport, orientation and retrieval robot

  • PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography

  • Small angle X-ray scattering (SAXS) Kratky camera system

  • Single crystal X-ray diffractometer with custom enclosure and flexibility for easy integration of accessory components

  • High resolution X-ray detectors for X-ray diffractometers from DECTRIS